Benzocaine Synthesis

Introduction: Naturally occu work party local anaesthetic agents save been used for all over a century to pall or alleviate the wound involved with medical procedures. Specifically, the pull of coca leaves was the first to be used. Its active ingredient, cocaine, was an effective anesthetic, just now its addictive t demiseencies caused it to be decrepit as an anesthetic and outlawed as a drug. With their greater effectiveness and fall side effects, synthetic anesthetics have fol depressed into common use. all important(p) to the effectiveness of many of these anesthetics is the aromatic ring at nonpareil end and possibly a standby or tertiary amine at the other end of the molecule, seperated by a one- to four-unit hydrocarbon chain. In this experiment, we will synthesize benzocaine, one of the simpler local anesthetics, from para-amino benzoic acid and ethanol in the bearing of conc. sulfuric acid. benzocaine is an odorless, white, rhombohedric cr ystal with low water solubility. It is peeled to light motion picture and to temperatures above 30° C. As a drug, it has a low potency and low systemic toxicity. It is as well as a possible sulfonamide antagonist. Experimental: 1.20 g of p-amino benzoic acid and 12.0 mL of ethanol were added to a round-bottom flaskful with a magnetic stirbar. The classification was left to stir until the cockeyed dissolved.

1.0 mL of conc. sulfuric acid was slowly added and the medley was allowed to genly work under reflux for about 75 minutes. After reaction, the mixture was allowed to cool and was transferr ed to a beaker containing 30 mL of water. ! 10% atomic number 11 carbonate solution was added until gas was no longer evolved and the pH was around 8. The benzocaine was collected using vacuum filtration and was rinsed with water. The ontogeny was allowed to air dry overnight. An infared spectrum in NUJOL was obtained, and the NMR spectrum in CDCl3 was run. send MW mass (g) vol (mL) d (g/mL) m. p. (° C) mol p-amino benzoic acid 137.14 1.2 - 1.374 188 -189...If you lack to abbreviate a full essay, order it on our website: OrderCustomPaper.com

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